Unit1
Unit 1: General Concepts
8 hrsVirus history, Diversity, shapes, sizes and components of genomes. Isolation and purification of viruses and components.
Syllabus
5 units · 40 lecture hoursUnit2
Unit 2
8 hrsConsequences of virus infection to animals and human. Viral infection: affect on host macromolecules. Viral infection: establishment of the antiviral state. Viruses counter attack mechanisms. Viral diagnostic techniques: Rapid Antigen testing, RTPCR.
Unit3
Unit 3
8 hrsClassification of viruses and nomenclatures. +strand RNA viruses- Picorna viruses. Flavi viruses- West Nile virus and Dengue virus. Corona viruses- SARS pathogens. Small DNA viruses: parvo- and polyoma viruses. Large DNA viruses: Herpes-adeno-, and poxviruses. Miscellaneous viruses.
Unit4
Unit 4
8 hrs–ve strand RNA viruses Paramyxo viruses. Orthomyxo viruses: Influenza pathogenesis and Bird flu. Rhabdo viruses: Rabies pathogenesis.. dsRNA viruses- Reo viruses. Retroviruses: structure, classification, life cycle; reverse transcription. Retroviruses: HIV, viral pathogenesis and AIDS.
Unit5
Unit 5
8 hrsAntivirals and viral vaccines Viral Vaccines Conventional vaccines-killed and attenuated, modern vaccinesrecombinant proteins, subunits, DNA vaccines, peptides, immunemodulators (cytokines), vaccine delivery and adjuvants, large scale manufacturing- QA/QC issues. Antivirals Interferons, designing and screening of antivirals, mechanism of action, antiviral libraries, antiretrovirals- mechanism of action and drug resistance. Modern approaches of virus control Anti-sense RNA, siRNA, ribozymes.
Course Objectives
- The objective of this course is to help the student learn molecular virology by general principles as opposed to describing each virus family. The rules for viral replication that all viruses follow are illustrated and discussed: while pointing out to the specific features of each virus, the course aims to reveal unity in the virus world rather than diversity. Host-pathogen interactions and examples of viral diseases will be discussed, with particular emphasis on the main principles of vaccine and antiviral drug development
Reference Books
- Antiviral Agents, Vaccines and immunotherapies. Stephen K. Tyring. ISBN 9780367393748 CRC
- Basic Virology – Edward K Wanger. Blackwell Publication
- Fundamentals of molecular virology – Acheson and Nicholas H,2011 4. Principles of Virology 2nd edition by S.J.Flint, L.W.Enquist, R.M.Krug,V.R. Racaniello, and A.M.Skalka ASM Press
- Medical Virology 4th edition by David O.White and Frank J. Fenner. Academic Press.
Official AKTU syllabus
This subject is on page 16, 17 of the original AKTU PDF.