UNIQUE SERIES AKTU Syllabus
BBI303

Computational Biology

L-T-P2-1-0 Credits3 Session2025-26 TypeTheory
Appears in 1 semester

B.Tech Bioinformatics · Sem 3 (Core)

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Syllabus

5 units · 40 lecture hours
Unit1

Unit 1

8 hrs

HISTORY, SCOPE AND IMPORTANCE -aims and tasks of Bioinformatics-applications of Bioinformatics - challenges and opportunities - introduction to NCBI data model- Various file formats for biological sequences

Unit2

Unit 2: DATABASES - TOOLS AND THEIR USES

8 hrs

Importance of databases - Biological databases-primary sequence databases- Composite sequence databases- Secondary databases- nucleic acid sequence databases - Protein sequence data bases - structure databases - bibliographic databases

Unit3

Unit 3: SEQUENCEALIGNMENTMETHODS

8 hrs

Sequence analysis of biological data-Significance of sequence alignment- pairwise sequence alignment methods-Use of scoring matrices and gap penalties in sequence alignments- multiple sequence alignment methods - Tools and application of multiple sequence alignment.

Unit4

Unit 4: PREDICTIVE METHODS USING DNA AND PROTEIN SEQUENCES

8 hrs

Gene predictions strategies - protein prediction strategies - molecular visualization tools phylogenetic analysis: Concept of trees- phylogenetic trees and multiple alignments

Unit5

Unit 5: DRUG DISCOVERY PROCESS

8 hrs

Discovering a drug-target identification and validation-identifying the lead compound- optimization of lead compound-chemical libraries.

Course Outcomes (COs)5 outcomes

After completion of the course student will be able to:

  1. CO1Recall the historical contributions, scope, and basic tools (NCBI, file formats) used in bioinformatics.K1
  2. CO2Understand the structure and purpose of various biological databases and describe their applications in biological research.K2
  3. CO3Apply methods of sequence alignment using scoring matrices and interpret results from multiple sequence alignment tools.K3
  4. CO4Analyze predictive methods like gene/protein prediction, molecular visualization, and phylogenetic analysis.K4
  5. CO5Explain and analyze the stages of the drug discovery pipeline including target identification, lead optimization, and chemical libraries.K4

Text Book (s)

  1. S.C. Rastogi & others, “Bioinformatics- Concepts, Skills, and Applications”, CBS Publishing, 2003.
  2. Andreas D Baxevanis & BF Francis,"Bioinformatics- Apracticalguide to analysis of Genes & Proteins",John Wiley, 2000.
  3. TK Attwood, DJ Parry-Smith, ”Introduction to Bioinformatics”, Pearson Education, 1stEdition, 11th Reprint 2005.
  4. CSV Murthy,”Bioinformatics”,Himalaya PublishingHouse,1st Edition 2003
  5. David W.Mount“Bioinformatics sequence andgenomeanalysis, Cold spring harbor laboratory press, 2004.
  6. S.Ignacimuthu ,S.J.,“Basic Bioinformatics’ ,Narosa Publishing House, 1995.

Official AKTU syllabus

This subject is on page 6 of the original AKTU PDF.

Official AKTU syllabus PDF ↗