UNIQUE SERIES AKTU Syllabus
BBI055

Biophysics

L-T-P3-0-0 Credits3 Session2026-27 TypeTheory
Appears in 1 semester

B.Tech Bioinformatics · Sem 5 (Departmental Elective-II)

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Syllabus

5 units · 40 lecture hours
Unit1

Unit 1: ELEMENTARY BIOPHYSICS RESEARCH

8 hrs

Definition of atom and its properties, size and charge of electron, nucleus, protons & neutrons. Types of interaction between atoms: Bond distance, Bond angle, Torsion Angle, H-bonding, VdW interactions, Hydrophobic interactions, Electrostatics interactions. Classical Mechanics: Newton’s laws of motion, Law of conservation of mass and energy. Thermodynamics: Laws, Enthalpy, Entropy, Free Energy, Gibbs & Helmholtz free energy, Internal energy.

Unit2

Unit 2: DNA BIOPHYSICS

8 hrs

Structure of A, B & Z forms of DNA with special emphasize to formation of phosphodiester bond, hydrogen bonding between the two strands of DNA, Helical parameters, DNA Backbone torsion angles, sugar back bone torsion angles, pseudo rotation, sugar puckering. Comparison of various parameters of A, B & Z forms of DNA.

Unit3

Unit 3: PROTEIN BIOPHYSICS

8 hrs

Amino acids, peptide bond, phi, psi & omega angles with distance, Zwitterion formation of amino acids, Levels of protein structure, Significance of Ramachandran Plot, Protein – DNA, drug, carbohydrate, small molecule interactions. Energetics of lipid bilayer. Molecular Mechanics & Dynamics protocol.

Unit4

Unit 4: CARBOHYDRATE BIOPHYSICS

8 hrs

Structure of D-glucose & D fructose; formation of glucosides & the cyclic structure of D- glucose; D-ribose & D-deoxyribose; Structure and conformation of disaccharides and polysaccharides-cellulose, amylose, amylopectin & glycogen, Chitin, carbohydrate conjugates. Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh

Unit5

Unit 5: TECHNIQUES IN BIOPHYSICS

8 hrs

X-ray crystallography, NMR, IR, Raman, AAS, UV, CD, Cosy, Noesy, spectroscopy, Mass spectrometry, Maldi TOF for protein prediction.

Course Outcomes (COs)5 outcomes

After completion of the course student will be able to:

  1. CO1Understand fundamental principles of biophysics including atomic interactions, mechanics, and thermodynamics.K2
  2. CO2Apply DNA biophysics concepts such as structural forms, torsion angles, and helical parameters.K3
  3. CO3Explain protein biophysics including peptide bonds, Ramachandran plots, and biomolecular interactions.K2
  4. CO4Explain carbohydrate biophysics covering monosaccharides, polysaccharides, and conjugates.K2
  5. CO5Apply X-ray crystallography, NMR, spectroscopy, Mass Spectrometry, and MALDI-TOF techniques to study biomolecules.K3

TEXT BOOKS

  1. / REFERENCES
  2. Carl Branden & John Tooze (1999), “Introduction to Protein Structure”, Garland Publishing, New York & London.
  3. Wolfram Saenger (1983), “Principles of Nucleic Acid Structure”, Springer- Verlag, New York.
  4. Andrew R. Leach (2000), “Molecular Modelling Principles and Applications”, Prentice Hall.
  5. Puri B.R., L.R. Sharma, M.S. Pathania (2008), “Principles of Physical Chemistry”, Vishal Publishing Company.
  6. Murugesan R. (2004), “Modern Physics”, S. Chand & Co.
  7. Vasantha Pattabhi & Gautham (2002), “Biophysics”, Narosa Publishing. Dr. A.P.J. Abdul Kalam Technical University, Lucknow, Uttar Pradesh

Official AKTU syllabus

This subject is on page 19, 20, 21 of the original AKTU PDF.

Official AKTU syllabus PDF ↗